They played an important role in the current composition of the forest, says the study.
Researchers found that species used for food or building materials were far more common near ancient settlements.
"So the Amazon is not nearly as untouched as it may seem," said Dr Hans ter Steege in the Netherlands.
Eighty-five species that produced Brazil nuts, cashew nuts, acai or rubber were also five times more likely to be dominant in mature forest than non-domesticated species.
The scientists reached their conclusions by comparing data on tree composition from more than 1,000 locations in the Amazon with a map of archaeological sites.-read more
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